@Dey_Gautam Well, we have worked on the NE a bit (https://t.co/Lkfo0z6vek). I am interested it all stuff related to cell architecture, and those NE membrane swirls are so cool!😍 But yeah, in terms of science-ing, it comes down to available hands, and we ar
@RibosomeStudio ...in case people want to know more about those "guardians", I'll leave this here. Thanks for making this cool image, @RibosomeStudio! It's was an awesome surprise🤩. https://t.co/ADkjlAEm4r
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
@RibosomeStudio NEAT!🤩 ...but where are the proteasomes attached to the NPC's nuclear basket? 😉🤪 https://t.co/ADkjlAVWVZ
RT @bengeliscious: It's raining 🐸 NPCs! Structures of the cytoplasmic ring (https://t.co/h2vztsn2Xo) and the luminal ring, proposed to serv…
RT @bengeliscious: It's raining 🐸 NPCs! Structures of the cytoplasmic ring (https://t.co/h2vztsn2Xo) and the luminal ring, proposed to serv…
RT @bengeliscious: It's raining 🐸 NPCs! Structures of the cytoplasmic ring (https://t.co/h2vztsn2Xo) and the luminal ring, proposed to serv…
RT @bengeliscious: It's raining 🐸 NPCs! Structures of the cytoplasmic ring (https://t.co/h2vztsn2Xo) and the luminal ring, proposed to serv…
RT @bengeliscious: It's raining 🐸 NPCs! Structures of the cytoplasmic ring (https://t.co/h2vztsn2Xo) and the luminal ring, proposed to serv…
RT @bengeliscious: It's raining 🐸 NPCs! Structures of the cytoplasmic ring (https://t.co/h2vztsn2Xo) and the luminal ring, proposed to serv…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: It's raining 🐸 NPCs! Structures of the cytoplasmic ring (https://t.co/h2vztsn2Xo) and the luminal ring, proposed to serv…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: It's raining 🐸 NPCs! Structures of the cytoplasmic ring (https://t.co/h2vztsn2Xo) and the luminal ring, proposed to serv…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: It's raining 🐸 NPCs! Structures of the cytoplasmic ring (https://t.co/h2vztsn2Xo) and the luminal ring, proposed to serv…
RT @bengeliscious: It's raining 🐸 NPCs! Structures of the cytoplasmic ring (https://t.co/h2vztsn2Xo) and the luminal ring, proposed to serv…
RT @bengeliscious: It's raining 🐸 NPCs! Structures of the cytoplasmic ring (https://t.co/h2vztsn2Xo) and the luminal ring, proposed to serv…
It's raining 🐸 NPCs! Structures of the cytoplasmic ring (https://t.co/h2vztsn2Xo) and the luminal ring, proposed to serve as a bumper between NPCs (https://t.co/gD8VXzigse). If conserved, the luminal ring is well positioned to membrane-tether proteasomes!
@Seb_Fica Thanks! Inside the nucleus like this? Or do you want higher mag for those nucleosomes? A lot of groups are going for that, so you won't have to dream long😉 For now, you can check out the work of @MitosisLab 👍 https://t.co/ADkjlAEm4r
@betenoire1 Yeah, I feel like our work often raises lots of questions rather than nailing down definitive answers. Oh well, that's the fun of exploration!🚀...But we will try to follow up on some of these questions. Those NPC-tethered proteasomes are still
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: I was looking through the Warp 3D denoising documentation (https://t.co/b4Qhc0zeRn) and thought to myself: "Where have I…
I was looking through the Warp 3D denoising documentation (https://t.co/b4Qhc0zeRn) and thought to myself: "Where have I seen that tomogram before?" (hint: https://t.co/GJQyBbcSpd). The denoising looks very nice for particle picking! 🧐 Let's pick and clas
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
@MitosisLab @caitaukueh @Mitosis_cryoET @EMDB_EMPIAR And a question-- were your nuclear proteasomes localized to NPCs like in Chlamy? (https://t.co/GJQyBbcSpd). We anticipate this, but we've had a hard time visualizing proteasomes in yeast. Your examples
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
@DTegunov @strangeatoms Thanks for the recommendation 😁 For a talk, you can try the movies in these papers: https://t.co/GJQyBbcSpd https://t.co/5hFJ7kchbp https://t.co/T8VLzql4GE For the corresponding bin4 tomos: https://t.co/IMaju6ukfL https://t.co/eex6
@Kaelberviridae @WimJHH @DmitryLyumkis ha ha.... after throwing out half of our tomograms for alignment quality, we still put 76 tomograms into this paper. It's not all just pretty single images: https://t.co/ADkjlAEm4r
RT @Beck_Laboratory: Finally online!! :) https://t.co/AEmLrsLRL9
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
@CryoCapCell Makes me think of this paper. There’s so much going on there! https://t.co/xL5c6Mg4cC
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
@florianjug @DTegunov We gave you some cellular tomograms to play with, right? @DTegunov ran Warp's denoising over this volume (https://t.co/ADkjlAEm4r) and I think it looks really promising for extracting all the particles. Then we just need to throw the
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
@DTegunov @mcianfro @Jen_Cash_11 @LanderLab @RadoDanev Is this the same decon filter that we have been using on our defocus tomograms (https://t.co/quGs862LKG)? That has given us great images for display and segmentation. It can make VPP-like contrast, but
RT @bengeliscious: Very Cool! I wonder if the NPC-tethered proteasomes (https://t.co/dhIVVPyT7t) are also somehow involved in regulating t…
Very Cool! I wonder if the NPC-tethered proteasomes (https://t.co/dhIVVPyT7t) are also somehow involved in regulating this NPC biogenesis pathway... perhaps by modulating the localization of Ulp1 to the NPC? Does acute proteasome inhibition (MG132) affec
@DrLachie @EdwinHawkins @pseudokinase I couldn't agree more!! https://t.co/mx6SdcpoB5 (also the end of this one: https://t.co/ADkjlAEm4r ) STAY ON TARGET!! https://t.co/gSqzS4yeI2
@DTegunov @WimJHH @QiangGuo_EM Haha, no Chlamy ALS model yet. Our Chlamy proteasomes almost hit 1/2 Nyquist (https://t.co/dhIVVPyT7t), but we were still particle limited. You obviously did better with an excess of ribosomes. @QiangGuo_EM had smaller pixels
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @sonyahans: This is totally insane (in the best kind of way): https://t.co/RpasgrHvLV
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
This is totally insane (in the best kind of way): https://t.co/RpasgrHvLV
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
48 . Proteasomes tether to two distinct sites at the nuclear #pore #complex https://t.co/Go6m4iJYaa
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @WallaceUcsf: ANOTHER awesome paper from my awesome former student! proteasomes at the NPC??!! why? how? find out in his paper! ht…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @WallaceUcsf: ANOTHER awesome paper from my awesome former student! proteasomes at the NPC??!! why? how? find out in his paper! ht…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @ChlamyAutophagy: A new exciting microscopy study by @bengeliscious lab showing proteasomes binding to NPCs in Chlamydomonas https://t.c…
Want to know where the proteasome is in the cell and who it is hanging out with? Albert et al. look at just that in their cryo-ET paper on NPC-associated proteasome: https://t.co/pmAx0TqMQn
RT @itskameronyall: You HAVE to watch this video. Cryo transmission electron TOMOGRAPHY. Cell imaging at the protein level, in situ, in…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
the latest and greatest from @bengeliscious -- it is pure science fiction -- but its true. We have molecular 'guardians' protecting the portals to our cells nuclei! https://t.co/DCgI2rmFjj
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
You HAVE to watch this video. Cryo transmission electron TOMOGRAPHY. Cell imaging at the protein level, in situ, in 3D. Now THAT is super resolution. https://t.co/kEVhGQ0Zek
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @ChlamyAutophagy: A new exciting microscopy study by @bengeliscious lab showing proteasomes binding to NPCs in Chlamydomonas https://t.c…
RT @meghanlarnold: This is insane in the membrane #mindblown https://t.co/rfCmyZbCCd
RT @ChlamyAutophagy: A new exciting microscopy study by @bengeliscious lab showing proteasomes binding to NPCs in Chlamydomonas https://t.c…
This is insane in the membrane #mindblown https://t.co/rfCmyZbCCd
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @ChlamyAutophagy: A new exciting microscopy study by @bengeliscious lab showing proteasomes binding to NPCs in Chlamydomonas https://t.c…
RT @ChlamyAutophagy: A new exciting microscopy study by @bengeliscious lab showing proteasomes binding to NPCs in Chlamydomonas https://t.c…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
Stop blowing my mind https://t.co/N6bAtZJqRI
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @bengeliscious: Guardians of the Gate: Proteasomes tether to NPCs, degrading proteins at the gateway between the cytoplasm and the nucle…
RT @OliBClarke: Ok this is super cool https://t.co/morwbqdZ1M