| Title |
Actin-dependent vacuolar occupancy of the cell determines auxin-induced growth repression
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, December 2015
|
| DOI | 10.1073/pnas.1517445113 |
| Pubmed ID | |
| Authors |
David Scheuring, Christian Löfke, Falco Krüger, Maike Kittelmann, Ahmed Eisa, Louise Hughes, Richard S. Smith, Chris Hawes, Karin Schumacher, Jürgen Kleine-Vehn |
| Abstract |
The cytoskeleton is an early attribute of cellular life, and its main components are composed of conserved proteins. The actin cytoskeleton has a direct impact on the control of cell size in animal cells, but its mechanistic contribution to cellular growth in plants remains largely elusive. Here, we reveal a role of actin in regulating cell size in plants. The actin cytoskeleton shows proximity to vacuoles, and the phytohormone auxin not only controls the organization of actin filaments but also impacts vacuolar morphogenesis in an actin-dependent manner. Pharmacological and genetic interference with the actin-myosin system abolishes the effect of auxin on vacuoles and thus disrupts its negative influence on cellular growth. SEM-based 3D nanometer-resolution imaging of the vacuoles revealed that auxin controls the constriction and luminal size of the vacuole. We show that this actin-dependent mechanism controls the relative vacuolar occupancy of the cell, thus suggesting an unanticipated mechanism for cytosol homeostasis during cellular growth. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 15% |
| United States | 1 | 8% |
| Germany | 1 | 8% |
| Austria | 1 | 8% |
| Unknown | 8 | 62% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 54% |
| Scientists | 4 | 31% |
| Science communicators (journalists, bloggers, editors) | 2 | 15% |
Mendeley readers
The data shown below were compiled from readership statistics for 176 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| China | 1 | <1% |
| Czechia | 1 | <1% |
| Unknown | 173 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 43 | 24% |
| Student > Ph. D. Student | 37 | 21% |
| Student > Master | 15 | 9% |
| Student > Bachelor | 13 | 7% |
| Professor > Associate Professor | 9 | 5% |
| Other | 25 | 14% |
| Unknown | 34 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 85 | 48% |
| Biochemistry, Genetics and Molecular Biology | 42 | 24% |
| Environmental Science | 3 | 2% |
| Unspecified | 1 | <1% |
| Mathematics | 1 | <1% |
| Other | 7 | 4% |
| Unknown | 37 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 December 2021.
All research outputs
#5,092,110
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#46,249
of 101,438 outputs
Outputs of similar age
#82,855
of 403,685 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#523
of 843 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 403,685 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 843 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.