Report for: Quantification of biological aging in young adults

Title	Quantification of biological aging in young adults
Published in	Proceedings of the National Academy of Sciences of the United States of America, July 2015
DOI	10.1073/pnas.1506264112
Pubmed ID	26150497
Authors	Daniel W. Belsky, Avshalom Caspi, Renate Houts, Harvey J. Cohen, David L. Corcoran, Andrea Danese, HonaLee Harrington, Salomon Israel, Morgan E. Levine, Jonathan D. Schaefer, Karen Sugden, Ben Williams, Anatoli I. Yashin, Richie Poulton, Terrie E. Moffitt
Abstract	Antiaging therapies show promise in model organism research. Translation to humans is needed to address the challenges of an aging global population. Interventions to slow human aging will need to be applied to still-young individuals. However, most human aging research examines older adults, many with chronic disease. As a result, little is known about aging in young humans. We studied aging in 954 young humans, the Dunedin Study birth cohort, tracking multiple biomarkers across three time points spanning their third and fourth decades of life. We developed and validated two methods by which aging can be measured in young adults, one cross-sectional and one longitudinal. Our longitudinal measure allows quantification of the pace of coordinated physiological deterioration across multiple organ systems (e.g., pulmonary, periodontal, cardiovascular, renal, hepatic, and immune function). We applied these methods to assess biological aging in young humans who had not yet developed age-related diseases. Young individuals of the same chronological age varied in their "biological aging" (declining integrity of multiple organ systems). Already, before midlife, individuals who were aging more rapidly were less physically able, showed cognitive decline and brain aging, self-reported worse health, and looked older. Measured biological aging in young adults can be used to identify causes of aging and evaluate rejuvenation therapies.

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Geographical breakdown

Country	Count	As %
United States	98	23%
United Kingdom	38	9%
Spain	25	6%
Germany	12	3%
Canada	11	3%
Mexico	8	2%
Australia	6	1%
Japan	6	1%
Chile	4	<1%
Other	65	15%
Unknown	155	36%

Demographic breakdown

Type	Count	As %
Members of the public	284	66%
Scientists	93	22%
Practitioners (doctors, other healthcare professionals)	40	9%
Science communicators (journalists, bloggers, editors)	11	3%

Mendeley readers

The data shown below were compiled from readership statistics for 1,039 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
United States	8	<1%
United Kingdom	6	<1%
Portugal	3	<1%
Austria	3	<1%
Korea, Republic of	3	<1%
Netherlands	2	<1%
Sweden	2	<1%
Russia	2	<1%
Denmark	2	<1%
Other	20	2%
Unknown	988	95%

Demographic breakdown

Readers by professional status	Count	As %
Researcher	200	19%
Student > Ph. D. Student	193	19%
Student > Master	103	10%
Student > Bachelor	92	9%
Other	66	6%
Other	230	22%
Unknown	155	15%

Readers by discipline	Count	As %
Agricultural and Biological Sciences	175	17%
Medicine and Dentistry	175	17%
Biochemistry, Genetics and Molecular Biology	120	12%
Psychology	99	10%
Neuroscience	55	5%
Other	208	20%
Unknown	207	20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1116. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2023.

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Outputs from Proceedings of the National Academy of Sciences of the United States of America

#367

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Outputs of similar age

#73

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Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America

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Altmetric has tracked 23,393,453 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.

So far Altmetric has tracked 99,360 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.5. This one has done particularly well, scoring higher than 99% of its peers.

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Quantification of biological aging in young adults

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