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PNAS

Quantification of biological aging in young adults

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, July 2015
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Citations

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614 Dimensions

Readers on

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1096 Mendeley
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6 CiteULike
Title
Quantification of biological aging in young adults
Published in
Proceedings of the National Academy of Sciences of the United States of America, July 2015
DOI 10.1073/pnas.1506264112
Pubmed ID
Authors

Daniel W. Belsky, Avshalom Caspi, Renate Houts, Harvey J. Cohen, David L. Corcoran, Andrea Danese, HonaLee Harrington, Salomon Israel, Morgan E. Levine, Jonathan D. Schaefer, Karen Sugden, Ben Williams, Anatoli I. Yashin, Richie Poulton, Terrie E. Moffitt

Abstract

Antiaging therapies show promise in model organism research. Translation to humans is needed to address the challenges of an aging global population. Interventions to slow human aging will need to be applied to still-young individuals. However, most human aging research examines older adults, many with chronic disease. As a result, little is known about aging in young humans. We studied aging in 954 young humans, the Dunedin Study birth cohort, tracking multiple biomarkers across three time points spanning their third and fourth decades of life. We developed and validated two methods by which aging can be measured in young adults, one cross-sectional and one longitudinal. Our longitudinal measure allows quantification of the pace of coordinated physiological deterioration across multiple organ systems (e.g., pulmonary, periodontal, cardiovascular, renal, hepatic, and immune function). We applied these methods to assess biological aging in young humans who had not yet developed age-related diseases. Young individuals of the same chronological age varied in their "biological aging" (declining integrity of multiple organ systems). Already, before midlife, individuals who were aging more rapidly were less physically able, showed cognitive decline and brain aging, self-reported worse health, and looked older. Measured biological aging in young adults can be used to identify causes of aging and evaluate rejuvenation therapies.

Twitter Demographics

Twitter Demographics

The data shown below were collected from the profiles of 428 tweeters who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1,096 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 8 <1%
United Kingdom 6 <1%
Portugal 3 <1%
Austria 3 <1%
Korea, Republic of 3 <1%
Netherlands 2 <1%
Sweden 2 <1%
Russia 2 <1%
Denmark 2 <1%
Other 20 2%
Unknown 1045 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 205 19%
Student > Ph. D. Student 197 18%
Student > Master 109 10%
Student > Bachelor 92 8%
Other 67 6%
Other 253 23%
Unknown 173 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 178 16%
Medicine and Dentistry 177 16%
Biochemistry, Genetics and Molecular Biology 123 11%
Psychology 101 9%
Neuroscience 57 5%
Other 234 21%
Unknown 226 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1136. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2023.
All research outputs
#12,113
of 24,482,039 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#392
of 101,233 outputs
Outputs of similar age
#71
of 267,077 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#4
of 917 outputs
Altmetric has tracked 24,482,039 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 101,233 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,077 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 917 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.