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Stretchable living materials and devices with hydrogel–elastomer hybrids hosting programmed cells

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, February 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

news
21 news outlets
blogs
3 blogs
twitter
7 X users
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2 patents
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2 Facebook pages
googleplus
1 Google+ user

Citations

dimensions_citation
216 Dimensions

Readers on

mendeley
426 Mendeley
Title
Stretchable living materials and devices with hydrogel–elastomer hybrids hosting programmed cells
Published in
Proceedings of the National Academy of Sciences of the United States of America, February 2017
DOI 10.1073/pnas.1618307114
Pubmed ID
Authors

Xinyue Liu, Tzu-Chieh Tang, Eléonore Tham, Hyunwoo Yuk, Shaoting Lin, Timothy K Lu, Xuanhe Zhao

Abstract

Living systems, such as bacteria, yeasts, and mammalian cells, can be genetically programmed with synthetic circuits that execute sensing, computing, memory, and response functions. Integrating these functional living components into materials and devices will provide powerful tools for scientific research and enable new technological applications. However, it has been a grand challenge to maintain the viability, functionality, and safety of living components in freestanding materials and devices, which frequently undergo deformations during applications. Here, we report the design of a set of living materials and devices based on stretchable, robust, and biocompatible hydrogel-elastomer hybrids that host various types of genetically engineered bacterial cells. The hydrogel provides sustainable supplies of water and nutrients, and the elastomer is air-permeable, maintaining long-term viability and functionality of the encapsulated cells. Communication between different bacterial strains and with the environment is achieved via diffusion of molecules in the hydrogel. The high stretchability and robustness of the hydrogel-elastomer hybrids prevent leakage of cells from the living materials and devices, even under large deformations. We show functions and applications of stretchable living sensors that are responsive to multiple chemicals in a variety of form factors, including skin patches and gloves-based sensors. We further develop a quantitative model that couples transportation of signaling molecules and cellular response to aid the design of future living materials and devices.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 426 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 425 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 103 24%
Researcher 63 15%
Student > Master 44 10%
Student > Bachelor 28 7%
Student > Doctoral Student 22 5%
Other 44 10%
Unknown 122 29%
Readers by discipline Count As %
Engineering 65 15%
Materials Science 56 13%
Biochemistry, Genetics and Molecular Biology 49 12%
Chemistry 38 9%
Agricultural and Biological Sciences 33 8%
Other 60 14%
Unknown 125 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 184. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2023.
All research outputs
#219,019
of 25,554,853 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#4,128
of 103,344 outputs
Outputs of similar age
#5,153
of 449,911 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#83
of 957 outputs
Altmetric has tracked 25,554,853 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 103,344 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.5. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 449,911 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 957 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.